Table of Contents:
  • Machine derived contents note: S nnov ation as a Key Success Factor in the Pharmaceutal
  • Industry
  • The Productvity aradox
  • The Blockbuster Imperative 5
  • Strategies or Growth 10
  • Do You Want to Be in This Industry? 13
  • Bargaining Power of Suppliers 15
  • Bargaining Pow er f uyers 15
  • Risk of Entry from P ential Com titors
  • Threat of Substitute Products 17
  • R egulative Forces 17
  • Rivalry a on Esablished C mpanies
  • Entering the Market Quickly 20
  • C on clu sion s 21
  • II Pharmaceutical nnovatio Teas Swi d 23
  • Largest Eco rnic Value-Added of GDP in Switzerland 23
  • Stable M arket G row th 25
  • Sound Productivity an Employment 30
  • Strong Support by Industry Associations 31
  • H ighly G lobal O rientation 33
  • CIomplx Industry and Product Classification
  • ragnimnted Market Structure. 39
  • Sonioine d Fi nancing Systems 43
  • Strict New D rug Registration 44
  • A ccurate Price Regulation 50
  • III. The Science and Technology Chaenge: Ho to d Ne
  • Drugs 53
  • Rise of the Biotechnology Industry: Boosting Innovation. 53
  • High Throughput Screening Fail Earlier, Succeed Sooner, 5
  • Combinatorial Chemistry: Cut Experimental Cycle Times
  • Bioinformatics: More than 100 Gigabyte of Data pe Day 60
  • Proteonmics: Profiting l rio the Human Genome Project
  • Genomics: Towards Individualization and Mass Castomizati 6
  • Pharmacogenorics: Create Tailormade Drugs
  • Molecular Design: From Experimenting to Analyt ic esgn 67
  • C onclusions 68
  • IV The Pipeline Managemen Chalenge: How to Shape the
  • nnovation Flow
  • The Importance of Pipeline Management
  • The Complexity of Drug Discover 75
  • The Diftrent Phases of the R&D Process
  • The R&D Process at HoffmannLa Roche
  • C onclusions 85
  • V I The Outsorcing and nternationalization Chaenge: t
  • Harness Outside nnovation 87
  • Impact o OOtsourcig on the Pharmaceutical Value Chain 87
  • Successful (ommercialization of a BreakFlhough Technology 9
  • Trends and Drivers of Internationalization 9
  • R&D Internationalization of Swiss Pharmaceutical Companies.. 102
  • Locations of Pharmaceutical R&D Abroad 10
  • Thre Prinipal Puoblens of Internationa R&D 10
  • VI Management Answers t Pharmaceutica R&D Chalet 117
  • Managing the Research-to-Dev eopmeg Handover. 117
  • Managing Human Resources 119
  • Managing Projects and the Portfolio
  • Managing Outsourcing Activities
  • Managing Intellectual Property Rights 127
  • Managing R&D S trategy at Schering 131
  • Managing Virtual Project Management Pools a Roche 33
  • Managing Uncertainty at Roche 135
  • Managing Know-how Transfer at Kao 136
  • Conclusions 137
  • SVI. Future Directions and T rends 139.